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CABHR
University of Wisconsin–Milwaukee
Helen Bader School of Social Welfare
Mailing Address:
P.O. Box 786
Milwaukee, WI 53201
Contact Us:
Phone 414-229-5008
Fax 414-229-2872
cabhr@uwm.edu

CABHR Research History

Since it was founded in 1991, CABHR has had a history of pursuing research with important implications for the treatment of addiction. Here’s a summary of some of the important research projects CABHR has conducted.

Project MATCH

CABHR served as the Milwaukee site of this national, multi-site, multi-year project, funded by the National Institute on Alcohol Abuse and Alcoholism, which tested patient-treatment matching hypotheses.

Researchers analyzed personality characteristics of 1,726 patients in relation to the treatments they received to determine if patients with certain characteristics fared better with one treatment over others. The participants, all of whom had alcohol use disorders, received one of three interventions: motivational enhancement therapy, cognitive behavioral skills therapy, or 12-step facilitation.

The scientists found that all three interventions worked equally well, but people without social support systems did better in the 12-step program, while those with state-trait anger problems succeeded best with motivational enhancement therapy. CABHR’s founding director, Allen Zweben, D.S.W., served as the principal investigator for the Milwaukee site.

Publications

Miller, W. R., Zweben, A., DiClemente, C. C. & Rychtarik, R. G. (1992). Motivational enhancement therapy manual: A clinical research guide for therapists treating individuals with alcohol abuse and dependence. Project MATCH Monograph Series, Vol. 2. Rockville MD: NIAAA.

Babor, T. F., Longabaugh, R., Zweben, A., Fuller, R. K., Stout, R. L., Anton, R. F., & Randall, C. L. (1994) Issues in the definition and measurement of drinking outcomes in alcoholism treatment research. Journal of Studies on Alcohol Supplement, 12, 101-11.

Carroll, K. M., Kadden, R. M., Donovan, D. M., Zweben, A., & Rounsaville, B. J. (1994) Implementing treatment and protecting the validity of the independent variable in treatment matching studies. Journal of Studies on Alcohol Supplement, 12, 149-55.

Donovan, D. M., Kadden, R. M., DiClemente, C. C., Carroll, K. M., Longabaugh, R., Zweben, A., & Rychtarik, R. (1994) Issues in the selection and development of therapies in alcoholism treatment matching research. Journal of Studies on Alcohol Supplement, 12, 138-148.

Zweben, A., Donovan, D.M., Randall, C.L., Barrett, D., Dermen, K., Kabela, E., McRee, B., Meyers, R., Rice, C., Rosengren, D., et al. (1994) Issues in the development of subject recruitment strategies and eligibility criteria in multisite trials of matching. Journal of Studies on Alcohol Supplement, 12, 62-69.

Zweben, A. & Cisler, R. (1996) Composite outcome measures in alcoholism treatment research: Problems and potentialities. Substance Use and Misuse, 31, 1783-1805.

Zweben, A. (1997) Project MATCH: Client outcomes similar with varied alcoholism treatments. Issues of Substance, 2(2), 2-4.

Project Match Research Group. (1997). Matching alcoholism treatments to client heterogeneity: Project MATCH Posttreatment drinking outcomes. Journal of Studies on Alcohol, 58(1), 7-29.

Project MATCH Research Group. (1997). Project MATCH secondary a priori hypotheses. Addiction, 92(12), 1671-1698.

Barrett, D. & Morse, P. (1998). Handling noncompliance. In Zweben, A., Barrett, D., Carty, K., McRee, B., Morse, P. & Rice, C. (Eds.), Strategies for Facilitating Protocol Compliance in Alcoholism Treatment Research. Project MATCH Monograph Series, Vol. 7, Rockville, MD: NIAAA, 33-63.

Carroll, K.M., Connors, G.J., Cooney, N., DiClemente, C.C., Donovan, D.M., Kadden, R.M., Longabaugh, R.L., Rounsaville, B.J., Wirtz, P.W. & Zweben, A. (1998). Internal validity of Project MATCH: Discriminability and integrity. Journal of Consulting and Clinical Psychology, 66(2), 290-303.

Carty, K, Rice, C. & Barrett,D. (1998). Strategies for maintaining compliance. In Zweben, A., Barrett, D., Carty, K., McRee, B., Morse, P. & Rice, C. (Eds.), Strategies for Facilitating Protocol Compliance in Alcoholism Treatment Research. Project MATCH Monograph Series, Vol. 7, Rockville, MD: NIAAA, 9-32.

Cisler, R., Holder, H.D., Longabaugh R., Stout, R. & Zweben, A. (1998). Actual and estimated replication costs for alcohol treatment modalities: Case study from Project MATCH. Journal of Studies on Alcohol, 59(5), 503-512.

Longabaugh, R., Wirtz, P.W., Zweben, A. & Stout, R.L. (1998) Network support for drinking, Alcoholics Anonymous and long-term matching effects, Addiction, 93(9), 1313-1333.

Mattson, M.E. & Del Boca, F.K., Carroll, K.M., Cooney, N.L., DiClemente, C.C., Donovan, D., Kadden, R.M., McRee, B., Rice, C., Rychtarik, R.G. & Zweben, A. (1998). Compliance with treatment and follow-up protocols in Project MATCH: Predictors and relationship to outcome. Alcoholism: Clinical and Experimental Research, 22(6), 1328-1339.

McRee, B. (1998). Project MATCH - A case study: The role of a coordinating center in facilitating research compliance in a multisite clinical trial. In Zweben, A., Barrett, D., Carty, K., McRee, B., Morse, P. & Rice, C. (Eds.), Strategies for Facilitating Protocol Compliance in Alcoholism Treatment Research. Project MATCH Monograph Series, Vol. 7, Rockville, MD: NIAAA, 93-110.

Morse, P. & Barrett, D. (1998). Involving and maintaining collaterals. In Zweben, A., Barrett, D., Carty, K., McRee, B., Morse, P. & Rice, C. (Eds.), Strategies for Facilitating Protocol Compliance in Alcoholism Treatment Research. Project MATCH Monograph Series, Vol. 7, Rockville, MD: NIAAA, 65-75.

Project MATCH Research Group. (1998). Matching alcoholism treatments to client heterogeneity: Project MATCH three-year drinking outcomes. Alcoholism: Clinical and Experimental Research, 22(6), 1300-1311.

Rice, C., Freda, L. & Lawson, C. (1998). Setting up and maintaining an electronic data base. In Zweben, A., Barrett, D., Carty, K., McRee, B., Morse, P. & Rice, C. (Eds.), Strategies for Facilitating Protocol Compliance in Alcoholism Treatment Research. Project MATCH Monograph Series, Vol. 7, Rockville, MD: NIAAA, 77-92.

Zweben, A. (1998). Why we wrote this monograph. In Zweben, A., Barrett, D., Carty, K., McRee, B., Morse, P. & Rice, C. (Eds.), Strategies for Facilitating Protocol Compliance in Alcoholism Treatment Research. Project MATCH Monograph Series, Vol. 7, Rockville, MD: NIAAA, 1-7.

Zweben, A., Barrett, D., Carty, K., McRee, B., Morse, P. & Rice, C. (Eds.) (1998). Strategies for Facilitating Protocol Compliance in Alcoholism Treatment Research. Project MATCH Monograph Series, Vol. 7, Rockville, MD: NIAAA.

Cisler, R.A. & Zweben, A. (1999) Development of a composite measure for assessing alcohol treatment outcome: Operationalization and validity. Alcoholism: Clinical and Experimental Research, 23(2), 263-271.

Holder, H.D., Cisler, R.A., Longabaugh, R., Stout, R.L., Treno, A.J., & Zweben, A. (2000). Alcoholism treatment and medical care costs from Project MATCH. Addiction, 95(7), 999-1013.

DiClemente, C.C., Carbonari, J.P., Zweben, A., Morrell, T. & Lee,R. (2001). Motivation hypothesis and causal chain analysis. In R.H. Longabaugh & P.W. Wirtz, (Eds.) Project MATCH Hypotheses. Results and Causal Chain Analyses. NIAAA Project MATCH Monograph Series, Vol. 8, Rockville, MD: NIAAA.

Project COMBINE

CABHR served as the Milwaukee site of this multi-site, multi-year project, which was the first national study to systematically evaluate the effectiveness of behavioral treatments both with and without the medications naltrexone and acamprosate for people with alcohol use disorders. The 1,383 participants received either medical management, brief therapy provided by a health care professional, or a combined behavioral intervention, which included elements of motivational enhancement therapy, coping skills training, and 12-step facilitation.

The main finding of the study was that patients who received naltrexone with medical management did better than those who received medical management and a placebo. Additionally, patients who received the combined behavioral intervention and placebo fared better than those who received medical management and a placebo.

Allen Zweben, D.S.W., founding director of CABHR, served as the principal investigator of the Milwaukee site. The National Institute on Alcohol Abuse and Alcoholism funded this study.

Publications

Anton RF, O'Malley SS, Ciraulo DA, et al. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. Journal of the American Medical Association. May 3 2006;295(17):2003-2017.

Zweben A, Barrett D, Berger L, Murray KT. Recruiting and retaining participants in a combined behavioral and pharmacological clinical trial. Journal of Studies on Alcohol Supplement. Jul 2005(15):72-81; discussion 65.

Miller WR, Locastro JS, Longabaugh R, O'Malley S, Zweben A. When worlds collide: blending the divergent traditions of pharmacotherapy and-psychotherapy outcome research. Journal of  Studies on Alcohol Supplement. Jul 2005(15):17-23; discussion 16-17.