Faculty Research Featured in Prestigious Magazine

Mahsa Ranji ResearchDr. Mahsa Ranji's group's recent optical studies on models of pulmonary oxidative stress is featured as cover page in Journal of Biomedical Optics (JBO). Her group has investigated tissue mitochondrial redox state in intact rat lungs in two models of pulmonary oxidative stress, namely Hyperoxia and Ischemia-Reperfusion, by their novel fluorescence imaging technology.

Ventilation with enhanced fractions of O2 (hyperoxia) is a common and necessary treatment for hypoxemia in patients with lung failure, but prolonged exposure to hyperoxia causes lung injury. Ischemia-reperfusion (IR) injury of lung tissue is common in lung transplant or crush injury to the chest.

Here, in collaboration with VA hospital, MCW and Marquette university scientists, they showed that hyperoxic and IR lung tissue have a more oxidized respiratory chain than control lung tissue, consistent with previously measured mitochondrial dysfunction in both hyperoxic and IR lungs.

The cover image in the JBO shows a comparison of volume rendered images of mitochondrial NADH, FAD and redox ratio (NADH/FAD) in two rat lungs, one hyperoxic (top), and the other normal.

Link to the Paper : http://spiedigitallibrary.org/jbo/resource/1/jbopfo/v17/i4/p046010_s1