Research Writings


Publication is the way that scientists communicate their findings with the rest of the world, but more importantly, the process of publication gives the scientist feedback on his or her work. It is often a lengthy process to have findings published.

Most papers that get published are "accepted with revisions", meaning that several points made by the reviewers had to be addressed by the author before the paper would be published. Many papers are rejected on the grounds of not having enough new data. When this happens, the scientist must either do much more work and resubmit the paper to the same journal, or try submitting the paper to another journal that may be more interested in the results.

Publication is vital to a scientist's career for two reasons. First, when universities are looking for new professors, they base their decision on the amount of important papers the candidates have published. Second, research costs money, and the people who give scientists money to conduct their work rely on publications as a measure of how much they have accomplished with the money they've been given (this is especially important if you want to continue to be funded by the same people year after year).


Publication is also vital to science as a whole. One of the cornerstones of the scientific process is the free exchange of information. As long as everyone publishes their results, science progresses foreward. If someone publishes a new finding, other scientists can use that information to expand their own work and build upon the new findings, rather than every scientist having to do every experiment independently. Similarly, publication is essential for each scientist, because the review process gives the researcher a broader view of the work, and often suggests fruitful paths that the scientist may not have otherwise taken.



AL-Rawajfah O, Stetzer F, Hewitt JB. Incidence and risk factors for adults nosocomial bloodstream infections in the United States, 2003, Infection Control and Hospital Epidemiology 2009 30:1036-1044.

Aleström, P, Begemann G, Carvan  MJ III, Cheng KC, Crosier K, Crosier P, Ekker S, Huttenlocher A, Kawakami K, Kelly G, Korzh, V, Lieschke G, Mione M, Neely MN, Neuhauss S, Trede NS. Views on four key questions about zebrafish research. Zebrafish. 2008, 5(1):9-24.

Audi, SH, Merker MP, Krenz GS, Ahuja T, Roerig DL, Bongard RD. Coenzyme Q1 redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxia.  J Appl Physiol 2008, 105: 1114-11126.

Audi, SH, Gan Z, Lindemer BJ, Bongard RD, Merker MP.  Quantification of mitochondrial membrane potential in intact pulmonary endothelial cells using rhodamine 123 and tetramethylrhodamine. (2009 Submitted)

Bongard, RD, Lindemer BJ, Krenz GS, Merker MP.  Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells.

Borthiry GR, Antholine WE, Myers JM,  Myers CR. Reductive activation of hexavalent chromium by human lung epithelial cells: generation of Cr(V) and Cr(V)-thiol species. Journal of Inorganiz Biochemistry. 2008, 102:1449-1462. PMC2497427.

Borthiry GR, Antholine WE, Myers JM,  Myers CR. Addition of DNA to Cr(VI) and cytochrome b5 containing proteoliposomes leads to generation of DNA strand breaks and Cr(III) complexes. Chemistry & Biodiversity. 2008, 5:1545-1557.

Carvan, M.J. III, Incardona JP, Rise ML. Meeting the challenges of aquatic vertebrate ecotoxicology. Bioscience 2008, 58:1015-1025.

Chen V, Gray-Murray J, Willis E.  A Community-based Participatory Research Approach to Child Health Disparities Community Health Improvement for Metcalfe Park and Concordia (CHIMC). Annual meeting Academy Health Research. 2008, June 8-10. (Abstract)

Corsi S, Bannerman R, Weber, D, Klaper R. Water- and sediment-quality effects on Pimephales promelas spawning vary along an agriculture-to-urban land-use gradient Ecol Appl (2009 submitted)

Crago J, Corsi S, Weber D, Bannerman R, Klaper R. Linking biomarkers to reproductive success of fathead minnows in streams with increasing urbanization. Chemosphere (2009 submitted)

Croom EL, Stevens JC, Hines, RN, Wallace, AD and Hodgson E. Human hepatic CYP2B6 developmental expression: The impact of age and genotype. Biochem Pharmacol. 2009,78:184-190. PMID: 19464434.

Cuneo BC, Strasburger JF, Niksch A, Ovadia M, Wakai RT.  An expanded Phenotype of maternal SSA/SSB Antibody-associated Fetal Heart Disease.  J Maternal Fetal Neonatal Medicine. 2008 (In press).

Drevnick PE, Roberts AP, Otter RR, Hammerschmidt CR, Klaper R, Oris JT. Mercury toxicity in livers of northern pike (Esox lucius) from Isle Royale, USA. Comp Biochem Physiol C Toxicol Pharmacol. 2008 Apr; 147(3):331-8. Epub 2008 Jan 12.

Drayna PC, McLellan SL, Simpson P, Li S-H, Gorelick MH.  Association between rainfall and pediatric emergency department visits for acute gastrointestinal illness. Env Health Persp (submitted)

Ge, X, Olson, A, Cai, S. and Sem, DS  Binding Synergy and Cooperativity in Dihydrodipicolinate Reductase: Implications for Mechanism and the Design of Bi-ligand Inhibitors. Biochemistry, 2008, 47:9966-9980.

Ge, X, Wakim, B and Sem, DS. Chemical proteomics-based drug design: target and antitarget fishing with a catechol-rhodanine privileged scaffold for NAD(P)(H) binding proteins. J. Med. Chem. 2008, 51:4571-4580.

Gorelick MH, Wagner D, McLellan S. Development and validation of a self-administered questionnaire to measure water exposures in children. Ambul Pediatr. 2008, 8:388-91.

Gorelick MH, McLellan SL, Wagner D, Klein J.  Water use and acute diarrheal illness in a United States metropolitan area. Epidemiol Infect (submitted)

Gray-Murray J, Willis E. Revisiting Childhood Immunizations. Today’s Urban Parent. 2008, August.

Harvala H, Bremner J, Kealey S, Weller B, McLellan S, Lloyd G, Staples E, Faggian F, Solomon T. Case report: Eastern equine encephalitis virus imported to the UK. J Med Virol. 2009 Feb;81(2):305-8.PMID: 19107960

Hewitt JB, Levin PF, & Al-Rawajfah O.  Environmental health influences on disease and injury. In M. Piano, L. Quinn, K. Lauer, & D. Klein (Eds). Clinical pathophysiology: Common problems and key risk factors. Philadelphia: Lippincott, Williams & Wilkins.  (In press)

Hines RN, Koukouritaki SB, Poch MT and Stephens MC. Regulatory polymorphisms and their contribution to interindividual differences in the expression of enzymes influencing drug and toxicant disposition. Drug Metab Revs. 2008, 40:263-301. PMID: 18464046

Hines RN. Ontogeny of drug metabolizing enzymes/pediatric exclusivity. In: Handbook of drug metabolism, 2nd Edition (Pearson PG and Wienkers LC, eds.), Informa Healthcare. 2008, Vol 183, Chapter 9, pp. 227-242.

Hines RN, Sargent D, Autrup H, Birnbaum LS, Brent RL, Doerrer NG, Hubal EC, Juberg DR, Olejniczak K, Portier CJ, Slikker W. Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric population. Toxicol Sci. 2009, 113:4-26. PMID: 19770482

Hines RN.The ontogeny of drug metabolism enzymes and implications for adverse drug events. Pharmacol Therap. 2008, 118:250-267. PMID: 18406467

Hutz, RJ, Carvan MJ III, Baldridge MG, Conley LK, King Heiden T. Environmental toxicants and effects on female reproductive function. Trends in Reproductive Biology. 2008, 2:1-11.

Jeter SN, McDermott CM, Bower PA, Kinzelman JL, Bootsma MJ, Goetz GW, McLellan SL. Bacteroidales diversity in ring-billed gulls (Laurus delawarensis) residing at Lake Michigan beaches. Appl Environ Microbiol. 2009 Mar;75(6):1525-33. Epub 2009 Jan 16.PMID: 19151182

Johnson S, Willis E, Mandic C, Dickinson K.  Pediatric Annals.  Community Matters for Child Health, 2009, pending.

King Heiden TC, Struble CA, Rise ML, Hessner MJ, Hutz RJ and Carvan MJ III. Molecular targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the zebrafish ovary: Insights into TCDD-induced endocrine disruption and reproductive toxicity. Reproductive Toxicology. 2008, 25:47-57.

King Heiden T, Struble C, Hessner M, Hutz RJ, and Carvan MJ III.Molecular targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the zebrafish ovary: Insights into TCDD’s reproductive toxicity. Reprod Toxicol 2008, 25:47-57.

Kinzelman J, McLellan SL, Amick A, Preedit J, Scopel CO, Olapade O, Gradus S, Singh A, Sedmak G. Identification of human enteric pathogens in gull feces at Southwestern Lake Michigan bathing beaches. Can J Microbiol. 2008 Dec;54(12):1006-15.PMID: 19096455

Klaper R, Crago J, Barr J, Arndt D, Setyowati K, Chen J. Toxicity biomarker expression in daphnids exposed to manufactured nanoparticles: changes in toxicity with functionalization. Environ Pollut. 2009 Apr; 157(4):1152-6. Epub 2008 Dec 17.

Klick DE, Shadley JD and Hines RN. Differential regulation of human hepatic flavin-containing monooxygenase 3 (FMO3) by CCAAT/enhancer-binding protein β (C/EBPβ) liver inhibitory and liver activating proteins. Biochem Pharmacol. 2008, 76:268-278. PMID: 18555208

Kothinti R, Blodgett A, Tabatabai NM, Petering DH.  Zinc Finger Transcription Factor Zn3-Sp1 Reactions with Cd2+.  Chem. Res. Toxicol. (In press)

Kothinti, R, Blodgett, AB, Petering, DH, Tabatabai, NM.  Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters: Possible reaction of cadmium with the zinc finger domain of Sp1.  Toxicol Appl Pharmacol. In press.

Kramer MA, Rettie AE, Rieder MJ, Cabacungan ET and Hines RN. Novel CYP2C9 promoter variants and assessment of their impact on gene expression. Mol Pharmacol. 2008, 73:1751-1760. PMID: 18310303

Krenz, GS, Bongard RD, Gastonguay A, Williams C, Lindemer BJ and Merker MP. Characterization of the threshold for NAD(P)H:quinone oxidoreductase (NQO1) activity in intact sulforaphane treated pulmonary arterial endothelial cells. (Submitted)

Kusik BW, Carvan MJ III, Udvadia AJ. Detection of Mercury in Aquatic Environments using EPRE Reporter Zebrafish. Marine Biotechnology. 2008, 10:750-757.

Liang HL, Whelan HT, Eells JT and Wong-Riley MT.  Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. Neuroscience. 2008, 153: 963-74

Magzamen S, VanSickle D, Rose LD, Cronk C. Environmental Pediatrics. Pediatric Annals (in press).

McCullough CR, Pullela PK, Im SC, Waskell L and Sem DS. 13C-Methyl isocyanide as an NMR probe for cytochrome P450 active sites. J. Biomol. NMR. 2009, 43:171-178.

McLellan SL, Huse SM, Mueller-Spitz SR, Andreishcheva EN, Sogin ML. Diversity and population structure of sewage-derived microorganisms in wastewater treatment plant influent. Environ Microbiol. 2009 Oct 16. [Epub ahead of print]

Morrison LJ, McLellan S, Sweeney L, Chan C, Macleod A, Tait A, Turner CM. Differential host responses to Trypanosoma brucei infection: a role for parasite genetic diversity. Infect Immun. 2010 Jan 19. [Epub ahead of print]

Morrison LJ, Tait A, McLellan S, Sweeney L, Turner CM, MacLeod A. A major genetic locus in Trypanosoma brucei is a determinant of host pathology. PLoS Negl Trop Dis. 2009 Dec 1;3(12):e557.PMID: 19956590

Mueller-Spitz SR, Stewart LB, McLellan SL. Reliability of mCP method for identification of Clostridium perfringens from faecal polluted aquatic environments. J Appl Microbiol. 2009 Oct 26. [Epub ahead of print]

Mueller-Spitz SR, Goetz GW, McLellan SL. Temporal and spatial variability in nearshore bacterioplankton communities of Lake Michigan. FEMS Microbiol Ecol. 2009 Mar;67(3):511-22.PMID: 19220863

Myers JM, Antholine WE, Myers CR. Hexavalent chromium causes the oxidation of thioredoxin in human bronchial epithelial cells. Toxicology. 2008, 246:222–233. PMC2386998

Myers CR, Myers JM. The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells. Toxicology. 2009, 257: 95–104.

Namdarghanbari MA, Meeusen J, Bachowski G, Giebel N, Johnson J, Petering DH.  Reaction of the zinc sensor FluoZin-3 with Zn(7)-metallothionein: Inquiry into the existence of a proposed weak binding site.  J Inorg Biochem.  [Epub ahead of print]

Olson, AL, Yao, H, Herdendorf, TJ, Miziorko, HM, Hannongbua, S, Saparpakorn, P, Cai, S and Sem, DS. Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism, Proteins, 2009, 75:127-138.

Paddock CD, Finley RW, Wright CS, Robinson HN, Schrodt BJ, Lane CC, Ekenna O, Blass MA, Tamminga CL, Ohl CA, McLellan SL, Goddard J, Holman RC, Openshaw JJ, Sumner JW, Zaki SR, Eremeeva ME. Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever. Clin Infect Dis. 2008 Nov 1;47(9):1188-96.

Patz JA, Vavrus SJ, Uejio CK, McLellan SL. Climate change and waterborne disease risk in the Great Lakes region of the U.S. Am J Prev Med. 2008 Nov;35(5):451-8.PMID: 18929971

Petering DH, Krezoski S, Tabatabai NM. Metallothionein Toxicology: Meta Ion Trafficking and Cellular Protection, Vol. 5 of Metal Ions in Life Sciences. A. Sigel, H. Sigel, R. K. O. Sigel, Eds.; The Royal Society of Chemistry. 2009, 5, 353-397.

Plesniak, LA, Botsch, K, Leibrand, M, Kelly, M, Sem, DS, Adams, JA, Jennings, PA. Transferred NOE and saturation transfer difference NMR studies of Novobiocin binding to EnvZ suggest a binding mode similar to DNA gyrase. Chemical Biology Drug Des. 2008, 71, 28-35.

Rana U, Kothinti R, Meeusen J, Tabatabai NM, Krezoski S, Petering DH.  Zinc binding ligands and cellular zinc trafficking: apo-metallothionein, glutathione, TPEN, proteomic zinc, and Zn-Sp1. J Inorg Biochem. 2008, 102:489-99.

Riess, ML, Camara, AK, Heinen, A, Eells, JT, Henry, MM and Stowe, DF. KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions. J Cardiovasc Pharmacol. 2008, 51: 483-91.

Schmoldt A, Udvadia AJ.  Exploring differential gene expression in zebrafish to teach basic molecular biology skills.  Zebrafish. 2009 Jun;6(2):187-99.

Szadkowski A, Myers CR. Acrolein oxidizes the cytosolic and mitochondrial thioredoxins in human endothelial cells. Toxicology. 2008, 243:164–176. PMC2220080

Smith LE, Carvan III MJ, Dellinger JA, Ghorai JK, White DB, Williams FE, Weber DN. Developmental selenomethionine and methylmercury exposures affect zebrafish learning. Neurotoxicol Teratol 2009, doi:10.1016/

Smith, LE, Carvan MJ III, White DC, Williams FE, Weber DN. 2009. Selenomethionine attenuates early life stage abnormalities but not adult learning deficits in zebrafish developmentally exposed to methylmercury. Neurotoxicology and Teratology online. 2009, October 23. DO: 10.1016/

Srinivasan SS, Strasburger JF.  Diagnosis of Fetal Arrhythmias.  Opinions in Pediatrics 2008, 20:522-531.

Strasburger J.  Fetal Electrophysiology, editorial to manuscript by Van Leeuwan P. Pace. 2008, May.

Strasburger J, Cheulkar B, Wakai R.  Magnetocardiography For Fetal Arrhythmias. Heart Rhythm Journal. 2008, 5(7): 1073-1076. 

Strasburger, JF and Wakai, RT.  Fetal Arrhythmias. Invited Review. Nature Reviews Cardiology. 2009. (In press)

Stelzer RV, Hutz RJ. Gold nanoparticles enter rat ovarian granulosa cells and subcellular organelles, and alter in-vitro estrogen accumulation. J Reprod Develop 2009/2010, 55:6 (in press).

Szadkowski A, Myers CR. Acrolein oxidizes the cytosolic and mitochondrial thioredoxins in human endothelial cells. Toxicology. 2008, 243:164–176. PMC2220080

Tabatabai NM, Sharma M, Blumenthal SS, Petering DH. Enhanced expressions of sodium-glucose cotransporters in the kidneys of diabetic Zucker rats.  Diabetes Res Clin Pract. 2009, 83:e27-30.

Tabatabai NM,  Blodgett AB, Kothinti, RK,  Petering DH.  Direct inhibitory effect of cadmium on DNA binding domain of transcription factor Sp1 as a mechanism for cadmium-induced decrease in SGLT mRNA. Toxicol. Appl Pharmacol. (In press)

Trasande L, Cronk C, Durkin M, Weiss M, Schoeller DA, Gall EA, Hewitt JB, Carrel AL, Landrigan PJ, Gillman MW. Environment and Obesity in the National Children's Study. 2009 Environ Health Perspectives 117(2):159-166.

Udvadia AJ. 3.6 kb genomic sequence from Takifugu capable of promoting axon growth-associated gene expression in developing and regenerating zebrafish neurons.  Gene Expr Patterns. 2008 Jul;8(6):382-8. Epub 2008 May 24.

Wang H, Huang P, Lie T, Li J, Hutz RJ, Li K, Shi F.  Reproductive toxicity of acrylamide-treated male rats.  Reprod Toxicol. 2010. (In press)

Watanabe, K, Andersen M, Basu N, Carvan MJ III, Crofton K, King K, Suñol C, Tiffany-Castiglioni E, Schultz I. Defining and Modeling Known Adverse Outcome Pathways: Domoic Acid and Neuronal Signaling as a Case Study. Environmental Toxicology and Chemistry. (In press)

Weber, DN, Connaughton VC, Dellinger JA, Klemer D, Udvadia A, Carvan  MJ III. Selenomethionine reduces visual deficits due to developmental methylmercury exposures. Physiology & Behavior. 2008, 93:250-260.

Willis E, Ngui E, Chen V, Cronk C, Meurer J, Shankle S, McManus P, Harvieux A. Navigating the Complexity of Relationships in Community-based Participatory Research (CBPR) In: Uncharted Path from Clinic-based to Community-based Research. 2008, New York: Nova Science Publishers. Chapter 9, 161-182.

Yao, H, Stuart, R, Cai, S, and Sem, DS. Structural characterization of the transmembrane domain from Subunit e (Su e) of yeast F1F0-ATP synthase: a helical GXXXG motif located just under the micelle surface. Biochemistry. 2008, 47:1910-1917.

Ying R, Liang HL, Whelan HT, Eells JT, Wong-Riley, MTT. Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone and MPP+ induced neurotoxicity. Brain Res. 2008, 1243: 167-173.

Zalstein S, Danne P, Taylor D, Cameron P, McLellan S, Fitzgerald M, Kossmann T, Patrick I, Walker T, Crameri J, Bailey M, Magilton G. The Victorian major trauma transfer study. Injury. 2010 Jan;41(1):102-9. Epub .PMID: 19615682

Zhao H, Cuneo B, Strasburger J, Huhta J, Gotteiner N, Wakai R. Electrophysiologic Characteristics of Fetal AV Block.  JACC. 2008, vol. 5, No. 1.

Zhu J, Meeusen J, Krezoski S,. Petering DH.  Reactivity of Zn-, Cd- and Apo-metallothionein with Nitric Oxide Compounds: In Vitro and Cellular Comparison. Chem. Res. Toxicol. (In press)