Wail Hassan, Ph.D., M(ASCP)CM
- Ph.D., Department of Biological Sciences,
The University of Southern Mississippi, 2004
- Diploma, Parasitology and Medical Entomology,
High Institute of Public Health,
Alexandria University, Egypt, 1993
- B.S., Microbiology,
Faculty of Science,
Alexandria University, Egypt, 1990
Enderis Hall, Room 469
Phone: (414) 229-3124
Fax: (414) 229-2619
Interests & Expertise
Human immunodeficiency virus type one (HIV-1) infection is generally a fatal disease. Most infected individuals progress to acquired immunodeficiency syndrome (AIDS) after an average of 10 years if left untreated. Some, however, control the virus to low, or even undetectable, levels and may survive for more than 20 years without developing AIDS. Multiple criteria are known to influence disease progression in HIV-1 disease and many of these criteria are established early during acute infection. My goal is to understand the underlying mechanisms of the early events that take place during acute HIV-1 infection, which seem to impact both the severity of the disease during the chronic phase and the timing of disease progression. Better understanding of these events is needed to define the initial insults exerted by the virus against the immune system, define the mechanisms leading to the initial failures of the immune system, and define correlates of protection that can be used as prognostic and vaccine development tools.
Wail M. Hassan, David A. Merin, Virginia Fonte, and Christopher D. Link. 2009. AIP-1 ameliorates β-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer’s disease model. Human Molecular Genetics, Vol. 18(15): 2739-2747.
Mathew Eberly, Muhamuda Kader, Wail Hassan, Kenneth A. Rogers, Jianzhong Zhou, Yvonne Mueller, Mary Mattapallil, Michael Piatak, Jr., Jeffrey D. Lifson, Peter D. Katsikis, Mario Roederer, Francois Villinger, and Joseph J. Mattapallil. 2009. IL-15 induced upregulation of CD4 is the primary cause for increased permissibility to SIV during acute infection. Journal of Immunology, Vol. 182(3): 1439-1448.
Muhamuda Kader, Wail M. Hassan, Mathew Eberly, Michael Piatak, Jeffrey D. Lifson, Mario Roederer, and Joseph J. Mattapallil. 2008. Anti-retroviral therapy prior to acute viral replication preserves CD4 T cells in the periphery but not in rectal mucosa during acute simian immunodeficiency virus infection. Journal of Virology, Vol. 82(22): 11467-11471.
Wail M. Hassan, Rudolph D. Ellender, and Shiao Y. Wang. Fidelity of bacterial source tracking: Escherichia coli vs Enterococcus spp and minimizing assignment of isolates from non-library sources. 2007. Journal of Applied Microbiology, Vol. 102: 591-598.
Sherif M. Karam, Wail M. Hassan, and Rony John. Expression of Retinoid Receptor in Multiple Cell Lineages in the Gastric Mucosae of Mice and Humans. 2005. Journal of Gastroenterology and Hepatology, Vol. 20(12): 1892-1899.
Wail M. Hassan, Shiao Y. Wang, and Rudolph D. Ellender. Methods to Increase Fidelity of Repetitive Extragenic Palindromic PCR Fingerprint-Based Bacterial Source Tracking Efforts. 2005. Applied and Environmental Microbiology, Vol. 71(1):512-8.
Sherif M. Karam, Timothy Straiton, Wail M. Hassan, and Charles Philippe Leblond. Defining Epithelial Cell Progenitors in the Human Oxyntic Mucosa. 2003. Stem Cells, Vol. 21(3):322-36.