Ching-Hong Yang
Ching-Hong Yang
Genomics, Functional Genomics and Host-Microbe Interactions

Ph. D. University of California, Riverside

Postdoctoral fellow
University of California, Riverside
University of California, Davis

Office: Lapham 131D
Phone: 414-229-6331
FAX: 414-229-3926

Research Interests

Application of functional genomic tools to investigate microbial gene expression in different environments
With the availability of complete genome sequences of different microorganisms, functional genomic tools provide a powerful approach for identifying microbial genes that are expressed during association of bacteria with their hosts in response to various environmental factors.In my current research, I am working on a project to sequence the complete genome of Dickeya dadantii 3937 (formerly named Erwinia chrysanthemi).D. dadantii is a common colonist of aerial plant surfaces and causes soft-rot, wilt and blight diseases on a wide range of plant species.Infection of plants by D. dadantii serves as a model for studying the mechanism of bacterial infection.My students and I are using complementary approaches to look at gene expression in this model organism. The first involves a custom designed microarray for D. dadantii that will enable us to look at sets of genes that are regulated over time during the infection process.Secondly, we are using in vivo expression techniques (IVET) to investigate specific genes of D. dadantii that are regulated in plant hosts.Thirdly, by using specific reporters combined with fluorescence-activated cell sorting, we explore genes of D. dadantii 3937 that are involved in type III secretion regulon and pathogenesis (T3SS).Using bioinformatic tools, T3SS-regulated genes identified in our study are used as a training set for a genome-wide identification of potential virulence genes in D. dadantii.
Genomic Tools

Developing T3SS inhibitors

The type III secretion system (T3SS) is a highly specialized protein secretion system that is essential to the virulence of many plant, animal, and human pathogens. The T3SS is an attractive target for development of antimicrobial compounds since it is present mainly in pathogenic gram-negative bacteria and is often required for virulence by these species. Several components of the T3SS are conserved among different pathogens, suggesting that an inhibitor targeted against such a component could be effective against a broad range of gram-negative pathogens, but not to affect normal microbial flora. A high throughput flow cytometry system combined with a green fluorescent protein-reporter has been established to screen potential T3SS inducers and inhibitors in our lab. My students and I identified two novel plant phenolic compounds, o-coumaric acid (OCA) and t-cinnamic acid (TCA), that induced the expression of T3SS genes in D. dadantii 3937. In addition, several analogs and isomers derived from OCA and TCA were selected and screened to identify compounds that inhibit the T3SS of the bacterium. An inhibitory phenolic compound, -coumaric acid, which blocks the T3SS pathway, was discovered. This is the first time that inducers and inhibitors of this system have been discovered in phytobacteria (Bacteria that are pathogenic to plants). Our goal is to investigate the structure-activity relationship in depth, to identify the active site(s) of the identified inhibitors, and ultimately to discover novel, potent, selective inhibitors of T3SS.

Developing novel approaches for microbial diversity profiling

The quantitative description of microbial communities is one of the most promising areas of research in microbial ecology. Classical culture based techniques recover only a small proportion of microorganisms from environmental samples, but have provided us with a wide array of products that have benefited humanity. New techniques in molecular ecology have now opened the door for a revolutionary advance in our understanding of microbial communities in nature and identification of new microorganisms and microbial products that can be harnessed for biotechnology. My students and I have been especially interested in developing novel approaches to analyze microbial diversity that is associated with plants. Going beyond these initial descriptions of microbial communities, my most recent work has begun to focus on interactions between plants and microorganisms using genome profiling. In addition, I would like to further explore how plant pathogens are influenced by the microbial communities with which they are associated and how gene expression is modified by environmental factors that influence both the pathogen and leaf bacterial communities. This research may lead to improved understanding of disease and methods for biocontrol by promoting disease suppressive bacterial communities on plant leaf surfaces.

Learning and Research Opportunities for Students
Undergraduate students with an interest in microbiology are welcome to enroll in an independent research study (BioSci290, BioSci689) in my lab. Research stipends are available to qualified undergraduate and graduate students.


Selected Publications in refereed journals. ('*' denotes corresponding author). Impact Factors (IF) are listed in the publications. 

Wu, X,, Q. Zeng, B. J. Koestler, C. M. Waters, G. W. Sundin, W. Hutchins, C.-H. Yang*. Deciphering the components that coordinately regulate virulence factors of the soft rot pathogen Dickeya dadantii. Mol. Plant-Microbe Interact. (in press). IF- 4.431

Li, Y., W. Hutchins, Xiaogang Wu, C. Liang, C. Zhang, X. Yuan, D. Khokhani, X. Chen, Y. Che, Q. Wang*, C.-H. Yang*. Derivative of plant phenolic compound inhibits the type III secretion system of Dickeya dadantii via HrpX/HrpY two-component signal transduction and rsm systems. Mol. Plant Pathol. (in press). IF- 3.877

Ma, J., A. M. Ibekwea*, D. E. Crowley, C.-H. Yang. 2014. Persistence of Escherichia coli O157 and non-O157 strains in Agricultural Soils. Sci. Total Environment. 490: 822-829. IF-3.258

Yang F., F. Tian, X. Li, S. Fan, H. Chen, M. Wu, C.-H. Yang, C. He*. 2014.The degenerate EAL-GGDEF domain protein Filp functions as a cyclic di-GMP receptor and specifically interacts with the PilZ-domain protein PXO_02715 to regulate virulence in Xanthomonas oryzae pv. oryzae. Mol. Plant-Microbe Interact. 27:578-589.. IF- 4.431

Tian, L., S. Xu, W. C. Hutchins, C.-H. Yang, J. Li*. 2014 Impact of the exopolysaccharides Pel and Psl on the initial adhesion of Pseudomonas aeruginosa to sand. Biofouling. 30:213-322. IF- 3.396

Chang, J. B. S. Mao, Y. Zhang, S. M. Cui, G. H. Zhou, X. G. Wu, C. H. Yang, and J. H. Chen*. 2013. Ultrasonic-assisted Self-assembly of Mono-layer Graphene Oxide for Detection of Escherichia coli," Nanoscale 5: 3620-3626. IF-6.233

Khokhani, D., C. Zhang, Y. Li, Q. Wang, Q. Zeng, A. Yamazaki, W. Hutchins, S.-S. Zhou, X. Chen*, C.-H. Yang*. 2013. Discovery of plant phenolic compounds that act as type three secretion system inhibitors or inducers of fire blight pathogen Erwinia amylovora.Appl. Environ. Microbiol. 79: 5424–5436. IF- 3.829

Ma, J., A. Ibekwe*, C.-H. Yang, D. E.Crowley. 2013. Influence of bacterial communities based on 454 pyrosequencing on the survival of Escherichia coli O157:H7 in soils. FEMS Microbiol. Ecol. 84:542-554. IF- 3.408

Wang, L., S. Xu, A. Yamazaki, C.-H. Yang, J. Li*. 2013. Laboratory Study of Escherichia coli O157:H7 Contamination in Groundwater. J. Environ. Eng. 10.1061/(ASCE)EE.1943-7870.0000786.IF-1.399

Ma, J., A. Ibekwe*, D. E.Crowley, C.-H. Yang. 2012. Persistence of Escherichia coli O157:H7 in major leafy green producing soils. Environ. Sci. Technol. 46:12154-12161. IF- 5.228

Ma, L., X. Liu, H. Liang, Y. Che, C. Chen, H. Dai, K. Yu, M. Liu, L. Ma, C.-H. Yang, F. Song, Y. Wang, and L. Zhang*. 2012. Effects of 14-alpha-lipoyl andrographolide on quorum sensing in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 56:6088-6094. IF- 4.841

Yang, F., F. Tian, L. Sun, H. Chen, M. Wu, C.-H. Yang, and C. He*. 2012. A novel two-component system PdeK/PdeR regulates c-di-GMP turnover and virulence of Xanthomonas oryzae pv. oryzae. Mol. Plant-Microbe Interact. 25: 1361-1369. IF- 4.431

Charkowski, A., C. Blanco, G. Condemine, D. Expert, T. Franza, C. Hayes, N. Hugouvieux-Cotte-Pattat, E. López Solanilla, D. Low, L. Moleleki, M. Pirhonen, A. Pitman, N. Perna, S. Reverchon, P. Rodriguez Palenzuela, M. San Francisco, I. Toth, S. Tsuyumu, J. van der Walls, J. van der Wolf, F. Van Gijsegem, C.-H. Yang, I. Yedidia. 2012. The role of secretion systems and small molecules in soft-rot enterobacteriace pathogenicity. Annu. Rev. Phytopathol. 50:425–449. IF- 9.875

Zou, L., Q. Zeng, H. Lin, G. Prasad, G. Chen, C.-H. Yang*. 2012. SlyA regulates T3SS genes in parallel with the T3SS master regulator HrpL in Dickeya dadantii 3937. Appl. Environ. Microbiol. 78: 2888–2895. IF- 3.829

Ma, J., A. M. Ibekwe1*, M. Leddy, C.-H. Yang, and D. E. Crowley. 2012. Assimilable organic carbon (AOC) in soil water extracts using Vibrio harveyi BB721 and its implication for microbial biomass. PloS ONE 7(5): e28519. IF- 4.092

Guo, W., L. Zou, Y. Li, Y. Cui, Z. Ji, L. Cai, H. Zou, W. C. Hutchins, C.-H. Yang*, and G. Chen*. 2012. Fructose-Bisphophate Aldolase Exhibits Functional Roles between Carbon Metabolism and the hrp System in Rice Pathogen Xanthomonas oryzae pv. oryzicola. PLoS ONE 7(2): e31855.IF- 4.092

Yamazaki, A., J. Li, Q. Zeng, D. Khokhani, W. C. Hutchins, A. C. Yost, E. Biddle, E. J. Toone, X. Chen*, C.-H. Yang*. 2012. Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS/GacA two component signal transduction system. Antimicrob. Agents Chemother. 56: 36-43. IF- 4.841

Zeng Q., M. D. Laiosa, D. A. Steeber, E. M. Biddle, Q. Peng, and C.-H. Yang*. 2012. Cell individuality: the bistable gene expression of T3SS in Dickeya dadantii 3937. Mol. Plant-Microbe Interact. 25:37-47. IF- 4.431

Ma, J., A. M. Ibekwe*, X. Yi, H. Wang, A. Yamazaki, D. E. Crowley, and C. H. Yang. 2011. Persistence of Escherichia coli O157:H7 and its mutants in soils. PLoS One 6:e23191. IF- 4.092

Li, Y. R., Y. Z. Che, H. S. Zou, Y. P. Cui, W. Guo, L. F. Zou, E. Biddle, C. H. Yang*, and G. Y. Chen*. 2011. Hpa2 required by HrpF to translocate Xanthomonas oryzae transcriptional activator-like effectors into rice for pathogenicity. Appl. Environ. Microbiol. 77: 3809-3818. IF- 3.829

Li, Y.-R. H.-S. Zou, Y.-Z. Che, Y.-P. Cui, W. Guo, L.-F. Zou, S. Chatterjee, E. M. Biddle, C.-H. Yang, and G.-Y. Chen*. 2011. A Novel Regulatory Role of HrpD6 in Regulating hrp-hrc-hpa Genes in Xanthomonas oryzae pv. oryzicola. Mol. Plant-Microbe Interact. 24: 1086-1101. IF- 4.431

Glasner, J. D., C. H. Yang, S. Reverchon, N. Hugouvieux-Cotte-Pattat, G. Condemine, J. P. Bohin, F. Van Gijsegem, S. Yang, T. Franza, D. Expert, G. Plunkett, 3rd, M. J. San Francisco, A. O. Charkowski, B. Py, K. Bell, L. Rauscher, P. Rodriguez-Palenzuela, A. Toussaint, M. C. Holeva, S. Y. He, V. Douet, M. Boccara, C. Blanco, I. Toth, B. D. Anderson, B. S. Biehl, B. Mau, S. M. Flynn, F. Barras, M. Lindeberg, P. R. Birch, S. Tsuyumu, X. Shi, M. Hibbing, M. N. Yap, M. Carpentier, E. Dassa, M. Umehara, J. F. Kim, M. Rusch, P. Soni, G. F. Mayhew, D. E. Fouts, S. R. Gill, F. R. Blattner, N. T. Keen, and N. T. Perna*. 2011. Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937. J. Bacteriol. 193: 2076-2077. IF- 3.825

Yamazaki, A., J. Li, W. C. Hutchins, L. Wang, J. Ma, A. M. Ibekwe, and C.-H. Yang*. 2011. Commensal effect of pectate lyases secreted from Dickeya dadantii on the proliferation of Escherichia coli O157:H7 EDL933 on lettuce leaves. Appl. Environ. Microbiol. 77:156-162. IF- 3.829

Yang, S., Q. Peng, Q. Zhang, L. Zou, Y. Li, C. Robert, L. Pritchard, H. Liu, R. Hovey, Q. Wang, P. Birch, I. K. Toth*, and C.-H. Yang*. 2010. Genome-wide identification of HrpL-regulated genes in the necrotrophic phytopathogen Dickeya dadantii 3937. PLoS ONE 5(10): e13472. IF- 4.092

Zeng, Q., A. M. Ibekwe, E. Biddle, and C.-H. Yang*. 2010. Regulatory mechanisms of exoribonuclease PNPase and regulatory small RNA on T3SS of Dickeya dadantii. Mol. Plant-Microbe Interact. 23: 1345-1355. IF- 4.431

Yi, X., A. Yamazaki, E. Biddle, Q. Zeng, and C.-H. Yang*. 2010. Genetic analysis of two phosphodiesterases reveals cyclic diguanylate regulation of virulence factors in Dickeya dadantii. Mol. Microbiol. 77:787-800. IF- 5.010

Li, Y., A. Yamazaki, L. Zou, E. Biddle, Q. Zeng, Y. Wang, H. Lin, Q. Wang*, and C.-H. Yang*. 2010. ClpXP protease regulates the Type III Secretion System of Dickeya dadantii 3937 and is essential for the bacterial virulence. Mol. Plant-Microbe Interact. 23:871-878. IF- 4.431

Ibekwe*, A. M., Papiernik, S. K., and C.-H. Yang. 2010. Influence of soil fumigation by methyl bromide and methyl iodide on rhizosphere and phyllosphere microbial community structure. J. Environ. Sci. Health B 45: 427-436. IF- 0.886

Ibekwe*, A. M., Papiernik, S. K., Grieve, C. M., and C.-H. Yang. 2010. Influence of fumigants on soil microbial diversity and survival of E. coli O157:H7. J. Environ. Sci. Health B 45: 416-426. IF- 0.886

Ibekwe*, A M., S. Papiernik, C. Grieve, and C.-H. Yang. 2009. Persistence of Escherichia coli O157:H7 on the rhizosphere and phyllosphere of lettuce. Lett. Appl. Microbiol. 49:784-790. IF- 1.622

Wang, S., L.-Y. Chang, Y.-J. Wang, Q. Wang*, C.-H. Yang, and R.-H. Mei. 2009. Nanoparticles affect the survival of bacteria on leaf surfaces. FEMS Microbiol. Ecol. 28: 182-191. IF- 3.408

Li, Y., Q. Peng, D. Selimi, Q. Wang, A. O. Charkowski, X. Chen, and C.-H. Yang*. 2009. The plant phenolic compound p-coumaric acid represses the Dickeya dadantii type III secretion system. Appl. Environ. Microbiol. 75:1223-1228. IF- 3.829

Yang, S., Q. Peng, M. San Francisco, Y. Wang, Q. Zeng, and C.-H. Yang*. 2008. Type III secretion system genes of Dickeya dadantii 3937 are induced by plant phenolic acids. PLoS ONE 3(8): e2973. IF- 4.092

Glasner, J. D., M. Marquez-Villavicencio, H.-S. Kim, C. E. Jahn, B. Ma, B. S. Biehl, A. I. Rissman, B. Mole, X. Yi, C.-H. Yang, J. L. Dangl, S. R. Grant, N. T. Perna1, A. O. Charkowski*. 2008. Niche-specificity and the variable fraction of the Pectobacterium pan-genome. Mol. Plant-Microbe Interact. 21:1549-60. IF- 4.431

Yap, M.-N., C. Rojas, C.-H. Yang, and A. O. Charkowski*. 2008. The response regulator HrpY of Dickeya dadantii 3937 regulates virulence genes not linked to the hrp cluster. Mol. Plant-Microbe Interact. 21: 304-314. IF- 4.431

Yang, S., Q. Peng, Q. Zhang, X. Yi, C. J. Choi, R. M. Reedy, A. O. Charkowski, and C.-H. Yang*. 2008. Dynamic regulation of GacA in type III secretion system, pectinase gene expression, pellicle formation, and pathogenicity of Dickeya dadantii. Mol. Plant-Microbe Interact. 21:133-142. IF- 4.431

Yang L., C.-H. Yang, and J. Li*. 2008. Adhesion and Retention of a Bacterial Phytopathogen Erwinia Chrysanthemi in Biofilm-Coated Porous Media. Environ. Sci. Technol. 42: 159–165. . IF- 5.228

Wang, Y.; H. Wang, C.-H. Yang, Q. Wang*, and R. Mei. 2007. Two distinct manganese-containing superoxide dismutase genes in Bacillus cereus: their physiological characterizations and roles in surviving in wheat rhizosphere. FEMS Microbiol. Lett. 272:206-213. IF-2.044

Yang, S., Q. Zhang, J. Guo, A. O. Charkowski, B. R. Glick, A. M. Ibekwe, D. A. Cooksey, and C.-H. Yang*. 2007. Global effect of Indole-3-acetic acid (IAA) biosynthesis on multiple virulence factors of Erwinia chrysanthemi 3937. Appl. Environ. Microbiol. 73:1079-1088. IF- 3.829

Ibekwe*, A. M., Grieve, C. M. and C.-H. Yang. 2007. Survival of E. coli O157:H7 in soil after fumigation by real-time PCR quantification. Can. J. Microbiol. 53:623-635. IF- 1.363

Ahn, S.-J., C.-H. Yang, and D. A. Cooksey*. 2007. Pseudomonas putida 06909 genes expressed during colonization on mycelial surfaces and phenotypic characterization of mutants. J. Appl. Microbiol. 103:120-32. IF- 2.337

Yang L., C.-H. Yang, and J. Li*. 2007. Influence of extracellular polymeric substances (EPS) on Pseudomonas aeruginosa transport and deposition profiles in porous media. Environ. Sci. Technol. 41:198-205. IF- 5.228

Ibekwea*, A. M., A. C. Kennedy, J. J. Halvorson,C.-H. Yang. 2007. Characterization of developing microbial communities in Mount. St. Helens pyroclastic substrate. Soil Biology & Biochemistry 39: 2496–2507. IF- 3.504

Okinaka, Y., N. T. Perna, S. Yang, N. T. Keen, and C.-H. Yang*. 2006. Identification of new virulence genes in Erwinia chrysanthemi 3937; transposon insertion into plant up-regulated genes. J. Gen. Plant Pathology 72: 360-368. IF- 0.689

Yap, M.-N., C. Rojas, C.-H., Yang, and A. O. Charkowski*. 2006. Harpin mediates cell aggregation in Erwinia chrysanthemi 3937. J. Bacteriol 188:2280-2284. IF- 3.825

Peng Q., S. Yang, A. O. Charkowski, M.-N. Yap, D. A. Steeber, N. T. Keen, and C.-H. Yang*. 2005. Population behavior analysis of dspE and pelD regulation in Erwinia chrysanthemi 3937. Mol. Plant-Microbe Interact. 19:451-457. IF- 4.431

Yang, L., Y.-H. Zhaoa, B.-X. Zhang, C.-H. Yang, and X. Zhang*. 2005. Isolation and characterization of a chlorpyrifos and 3,5,6-trichloro-2-pyridionol degrading bacterium. FEMS Microbiol. Lett. 251:67-73. IF- 2.044

Kawai T., C.-H. Yang, M. R. Matsumoto, D. E. Crowley, and J. D. Sheppard*. 2005. Comparison of PCR-DGGE and selective plating methods for monitoring the dynamics of a mixed culture population in synthetic brewery wastewater. Biotechnol. Prog. 21:712–719. IF- 2.304

Yap, M.-N., C.-H. Yang, J. D. Barak, and A. O. Charkowski*. 2005. The Erwinia chrysanthemi type III secretion system is required for multicellular behavior. J. Bacteriol. 187:639-648. IF- 3.825

Alvey S., C.-H. Yang, A. Buerkert*, D. E. Crowley. 2005. Bacterial ecology of ancient Saharan salt-enrichment ponds at Teguidda-n-Tessoumt. J. Plant. Nutr. 168:489-495. IF-0.526

Ibekwe*, A. M., S. K. Papiernik, C.-H. Yang. 2004. Enrichment and molecular characterization of chloropicrin- and metam-sodium-degrading microbial communities. Appl. Microbiol. Biotechnol.66:325-332. IF- 3.425

Yang, S., N. T. Perna, D. A. Cooksey, Y. Okinaka, S. E. Lindow, A. M. Ibekwe, N. T. Keen, and C.-H Yang*. 2004. Genome-wide identification of plant-upregulated genes of Erwinia chrysanthemi 3937 using a GFP-based IVET leaf array.Mol. Plant-Microbe Interact. 17:999-1008. IF- 4.431

Marschner*, P., D. Crowley and C.-H. Yang. 2004. Development of specific rhizosphere bacterial communities in relation to plant species, nutrition and soil type. Plant and Soil. 261: 199-208. IF- 2.733

Alvey, S., C.-H. Yang, A. Buerkert, and D. E. Crowley*. 2003. Cereal/legume rotation effects on rhizosphere bacterial community structure in West African soils. Biol Fert. Soils 37:73-82. IF- 2.319

Yang, C.-H., M. Gavilanes-Ruiz, Y. Okinaka, R. Vedel, I. Bethuy, M. Boccara, J. W. Chen, N. T. Perna, and N. T. Keen*. 2002. hrp genes of Erwinia chrysanthemi 3937 are important virulence factors. Mol. Plant-Microbe Interact. 15:472-480. IF- 4.431

Okinaka*, Y., C.-H. Yang, N. T. Perna and N. T. Keen. 2002. Microarray profiling of Erwinia chrysanthemi 3937 genes that are regulated during plant infection. Mol. Plant-Microbe Interact. 15:619-629. (MPMI Spotlight and cover page) IF- 4.431

Okinaka*, Y., C.-H. Yang, E. Herman, A. Kinney, and N. T. Keen. 2002. The P34 elicitor interacts with a soybean photorespiration enzyme, NADH-dependent hydroxypyruvate reductase. Mol. Plant-Microbe Interact. 15:1213-1218. IF- 4.431

Luepromchai, E., A. C. Singer, C.-H. Yang and D. E. Crowley*. 2002. Interactions of earthworms with indigenous and bioaugmented PCB-degrading bacteria. FEMS Microbial. Ecol. 41: 191-197. IF- 3.408

Ibekwe* A. M., A. C. Kennedy, P. S. Frohne, S. K. Papiernik, C.-H. Yang, and D. E. Crowley. 2002. Microbial diversity along a transect of agronomic zones. FEMS Microbial. Ecol. 39:183-191. IF- 3.408

Yang, C.-H., D. E. Crowley, J. Borneman, and N. T. Keen*. 2001. Microbial phyllosphere populations are more complex than previously realized. Proc. Natl. Acad. Sci. USA 98:3889-3894. IF- 9.681

Yang, C.-H., D. E. Crowley*, and J. A. Mange. 2001. 16S rDNA fingerprinting of rhizosphere bacterial communities associated with healthy and phytophthora infected avocado roots. FEMS Microbial. Ecol. 35:129-136. IF- 3.408

Marschner*, P., C.-H. Yang, R. Lieberei, D. E. Crowley. 2001. Soil and plant specific effects on bacterial community composition in the rhizosphere. Soil Biol. Biochem. 33:1437-1445. IF- 3.504

Ibekwe* A. M., S. K. Papiernik, J. Gan, S. R. Yate, D. E. Crowley, and C.-H. Yang. 2001. Microcosm enrichment of 1, 3-Dichloropropene-degrading microbial communities. J. of Appl. Microbiol. 91:668-676. IF- 2.337

Ibekwe* A. M., S. K. Papiernik, J. Gan, S. R. Yate, C.-H. Yang, and D. E. Crowley. 2001. Impact of fumigants on soil microbial community. Appl. Environ. Microbiol. 67:3245-3257. IF- 3.829

Yang*, C.-H., D. E. Crowley, G. H. Anthony, and N. T. Keen. 2000. Strain level identification of Pseudomonas using denaturing gradient gel electrophoresis of 16S-23S spacer region rDNA. J. Gen. Plant Pathology 66:225-233. IF- 0.689

Yang, C.-H., and D. E. Crowley*. 2000. Rhizosphere microbial community structure in relation to root location and plant iron nutritional status. Appl. Environ. Microbiol. 66:345-351. IF- 3.829

He X., K. Harper, G. Grantham, C.-H. Yang, R. Creamer*. 1998. Serological characterization of the 3 '-proximal encoded proteins of beet yellows closterovirus. Arch. Virol. 143: 1349-1363. IF- 2.111

Yang, C.-H., H. R. Azad, and D. A. Cooksey*. 1996.A chromosomal locus required for copper resistance, competitive fitness, and cytochrome c biogenesis in Pseudomonas fluorescens. Proc. Natl. Acad. Sci. USA 93:7315-7320. IF- 9.681

Yang, C.-H., J. A. Menge, and D. A. Cooksey*. 1994. Mutation affecting hyphal colonization and pyoverdine production in pseudomonads toward Phytophthora parasitica. Appl. Environ. Microbiol. 60:473-481. IF- 3.829

Yang, C.-H., J. A. Menge, and D. A. Cooksey*. 1993. Role of copper resistance in competitive survival of Pseudomonas fluorescens in soil. Appl. Environ. Microboil. 57:580-584. IF- 3.829

Books and Monographs:

Zeng, Q., and C.-H. Yang. Post-transcriptional and post-translational regulatory mechanisms for virulence factors. In G. Sundin et al. (eds.) Virulence mechanism of phytopathogenic bacteria. APS PRESS. St. Paul, MN (Book chapter) (in press).

Yang, C.-H. and S.-H. Yang. 2008. Managing bacterial plant diseases by modulating quorum sensing and Type III secretory systems. In: Z.K. Punja, S.H. De Boer and H. Sanfacon (eds.) Biotechnology and Plant Disease Management. CABI Publishing. Oxfordshire. UK. P. 16-57. (Book chapter)

Crowley*, D.E., E.S. Gilbert, A. Singer, D. Newcombe, and C.-H. Yang. 1999. Bioremediation of organic contaminants using repeated applications of xenobiotic degrading bacteria. In:R. Fass, Y Flashner, and S. Reuveny (eds.) Novel Methods for Bioremediation of Organic Pollution. Plenum Press. NY. p. 273-284.



Keen*, N. T., C. K. Dumenyo, C.-H. Yang, and D. A Cooksey. 2000. From rags to riches: insights from the first genomic sequence of a plant pathogenic bacterium. Genome Biology 1: 1019.1-1019.4.

Keen*, N. T. and C.-H. Yang. 1999. Functional genomics: Plant-Microbe interactions gingerly puts a foot in the water. Physiol. and Mol. Plant Pathology 55:313-315.