Terry S. Clayton

Ph.D. Student

Expected Year of Graduation: 2011
Research Lab: James Cook
Major Area of Focus: Organic Chemistry
Minor Area of Focus: Analytical Chemistry
Previously Attended:
UW-Madison, 1996, B.S.

Why I like Chemistry:

I have dedicated life to manipulating matter to create useful products for society.

Why I chose the Chemistry and Biochemistry Program at UW-Milwaukee:

I enjoy the culture at UWM. It's a nice balance of industry and academic pursuit.

Favorite things to do in Milwaukee:

I like to meet leaders of startups and look for ways to help them become successful.

Research Goals:

My research goals are to continue to develop new chemistries and scale up manufacturing process to create new and innovative products for the world.

Partial List of Patents:

Roth, B.; Clayton, T. Device, method, and composition for reducing the incidence of tobacco smoking. U.S. Pat. 7,766,018; August 03, 2010.

Cook, J.M.; Clayton, T.; Johnson, Y.T., Rallapalli, S.; Han, D.; Gabaergic Agents to Treat Memory Deficits. U.S. Pat. Appl. US 2010/0130479 A1. Pub. May 27, 2010.

Cook, J.M.; Han, D.; Clayton, T. Imidazobenzodiazepines as gabaergic agents to treat memory deficits and their preparation. U.S. Pat. 7,595,395 B2; September 29, 2009.

Cook, J.M.; Clayton, T.; Jain, H.D.; Teng, Y.; Yang, J. Selective Anticonvulsant Agents and Their Uses. U.S. Pat. Appl. No. 61/038,184; Filed March 2008.

Barndt, J.A.; Barton, R.H.; Clayton, T.S.; Rose, M.J.; Volz, P.G. Printing Using Color Changeable Material. WO 2009/094063 A1. Pub. July 30, 2009.

Graushar, W.T; Barndt, J.A.; Barton, R.H.; Clayton, T.S..; Ablative Printing. US 2009/0128860 A1; Pub. May 21, 2009.

Selected Publications:

Yin, W.; Majumder, S.; Clayton, T.; Petrouc, S.; VanLinn, M.L.; Namjoshia, O.A.; Ma, C.; Cromer, B.A.; Roth, B.L.; Platte, D.M. and Cook, J.M. Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse. Bioorg. and Med. Chem, 18, (21) pp 7548-7564(2010).

Miroslav M Savic, Ph.D.; Samarpan Majumder; Shengming Huang; Rahul V Edwankar; / Roman Furtmüller; Srđan Joksimović; Terry Clayton Sr; Joachim Ramerstorfer; Marija M Milinković; Bryan L Roth; Werner Sieghart; James M Cook Novel positive allosteric modulators of GABAA receptors: Do subtle differences in activity at a1 plus a5 versus a2 plus a3 subunits account for dissimilarities in behavioral effects in rats? Progress in Neuro-Psychopharmacology & Biological Psychiatry. Accepted in January 2010.

Grant, J.A., Bonnick, T., Gossell-Williams, M., Clayton, T., Cook, J.M., Jackson, Y.A., Synthesis, pharmacological studies and molecular modeling of some tetracyclic 1,3-diazepinium chlorides. Bioorg. Med. Chem. xxx (2009) xxx–xxx. Available online.

Takahashi, A.; Yap, J.J.; Bohager, D.Z.; Faccidomo, S.; Clayton, T.; Cook, J.M.; Miczek, K.A Glutamatergic and GABAergic Modulations of Ultrasonic Vocalizations During Maternal Separation Distress in Mouse Pups. Psychopharmacol. (Berlin, Ger.) , 204, pp 61-71 (2009).

Han, D., Forsterling, H.F., Li, X., Deschamps, J.R., Parrish, D., Cao, H., Rallapalli, S., Clayton, T. , Teng, Y., Majumder, S., Sankar, S., Roth, B.L., Sieghart, W., Furtmuller, R., J.K. , Weed, M.R., Cook, J.M. A Study of the Structure-activity Relationship of GABAA-benzodiazepine Receptor Bivalent Ligands by Conformational Analysis with low Temperature NMR and X-ray Analysis, Bioorg. and Med. Chem., 16, 8853-8862 (2008).

Savic, M.M., Huang, S., Furtmüeller, R., Clayton, T., Huck, S., Obradović, D.I., Ugrešić, N.D., Sieghart, W., Bokonjić, D.R., Cook, J.M.; Are GABAA Receptors Containing α5 Subunits Contributing to the Sedative Properties of Benzodiazepine Site Agonists? Neuropsychopharmacology, 2008, 33, pp 332–339.

Savic, M. M.; Clayton, T.; Furtmuller, R.; Gavrilovic, I.; Samardzic, J.; Savic, S.; Huck, S.; Sierhart, W.; Cook, J. M.; PWZ-029, A compound with moderate inverse agonist functional selectivity at GABAA receptors containing 5 subunits, improves passive, but not active, avoidance learning in rats. Brain Research, 2008,1208, pp 150-159.

Danni Harris, Terry Clayton, James Cook, Robert Halliwell, Peyman Sahbaie, Roman Furtmuller, Sigismund Huck, Werner Sieghart,Timothy M. DeLorey; Selective Influence on Contextual Memory: Physiochemical Properties Associated with Selectivity of Benzodiazepine Ligands at GABAA Receptors Containing the α5 Subunit. J. Med. Chem., 2008, 51 (13), pp 3788–3803.

T. Clayton, J.L. Chen, M. Ernst, L. Richter, B.A. Cromer, C.J. Morton, H. Ng, C.C. Kaczorowski, F.J. Helmstetter, R. Furtmüller, G. Ecker, M.W. Parker, W. Sieghart and J.M. Cook.; Analysis of the Benzodiazepine Binding Site on γ-Aminobutyric acidA Receptors: Correlation of Experimental Data with Pharmacophore and Comparative Models, Current Medicinal Chemistry, Vol. 14, number 26, Pp. 2755-2775; 2007.

Savic, M.M., Huang, S., Furtmüeller, R., Clayton, T., Huck, S., Obradović, D.I., Ugrešić, N.D., Sieghart, W., Bokonjić, D.R., Cook, J.M.; Are GABAA Receptors Containing α5 Subunits Contributing to the Sedative Properties of Benzodiazepine Site Agonists? Neuropsychopharmacology, 2008, 33, pp 332–339.


Clayton, Terry; Computational Chemistry Methods: SAR, Pharmacophores & Protein Docking. University of Wisconsin-Milwaukee, March 2nd, 2010.

Clayton, Terry; Synthesis of subtype selective ligands and molecular modeling for alpha-5 containing GABAA/Bz receptors to treat memory deficits. 235th ACS National Meeting, New Orleans, LA United States, April 6-10th , 2008.

J. A. Grant, Y. A. Jackson, M. Gossell-Williams, T. Bonnick, T. Clayton and J. M. Cook; Synthesis, Pharmacological Studies and Molecular Modeling of Novel Tetracyclic 1,3-Diazepinium Chlorides The 22nd Mona Symposium on Natural Products and Medicinal Chemistry, Mona Jamaica, January 7-10 (2008).

James M. Cook, Harry June, Elise Weerts, Micheal L. Van Linn, Donna Platt, Tim / DeLorey, Miroslav Savic, Terry Clayton. Serendipity rediscovered — an oxymoron or rational drug design: Studies on subtype selective BzR/GABAergic ligands. Division of Medicinal Chemistry-234th ACS National Meeting Boston, MA August 19-23, 2007.

Clayton, T.; Synthesis of Subtype Selective Ligands for Alpha 5-Containing GABAA/Bz Receptors to Treat Memory Deficits. 233rd ACS National Meeting, Chicago, IL, United States, March 25-29th, 2007.

Huang, Shengming; Savic, Miroslav; Furtmuller, Roman; Duke, Angela; Clayton, Terry; Sieghart, Werner; Rowlett, James K.; Cook, James M. Design and synthesis of stereoenantiomeric benzodiazepine receptor ligands. Abstract of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29th, 2007.

Platt, D.M.; Cook, J.M.; Van Linn, M.L.; Clayton, T.S.; GABA-A/alpha5 Receptor Mechanisms in the Discriminative Stimulus Effects of GABA-A Modulators. CPDD Meeting, Quebec, Canada. June 16-21, 2007.

M. Weed, T. Clayton, J.M. Cook, Ry-023, a Selective Inverse Agonist at the Benzodiazepine Binding Site on the GABA-A α5 Receptor, Improves Performance in a Delayed-Match-to-Sample Task in Rhesus Monkeys. 46th American College of Neuropsychopharmacology, December 9-13, Boca Raton, FL, Abst. #158 (2007).

Faccidomo, S.; Maggin, J.G.; Melief, S.; Clayton, T.S.; Cook, J.M.; Miczek, K.A. Modulation of Alcohol-Heightened Aggression in Mice by a5-Containing GABAA Receptors; Society for Neuroscience, Atlanta, GA October, 2006.

Grant, J.A..; Jackson, Y.A.; Gossel-Williams, M.; Clayton, T.; Cook, J.M.; Synthesis, Pharmacological Studies, and Molecular Modeling of Novel 1,3-Diazipinium Chlorides. In Latest Trends in Organic Synthesis, Brock University, St. Catherines, Ontario, 2006.

Clayton, T.; Sanker, S.; Delorey, T.; Sieghart, W.; Furtmueller, R.; Wenger, G.; Cook, J.M.; Synthesis of Subtype Selective Ligands for α5-Containing GABAA/Bz Receptors to Treat Memory Deficits. ACS, Milwaukee, WI, May, 2006.

S. Huang, T. Clayton, M. Dai, W. Yin, J. Ma, R. Edwankar, C. Sawant, M. Van Linn, Y. Teng, M. Johnson, H. F. Forsterling, and J. M. Cook; The SAR Study of Benzodiazepine Receptor Bivalent Ligands by Low Temperature NMR Spectroscopy and X-Ray Analysis , Abstracts, 37th Great Lakes Regional Meeting of the American Chemical Society, Milwaukee, WI May 31 – June 2, 2006, GLRM-155.

S. Huang, T. Clayton, M. Dai, R. Edwankar, C. Sawant, J. M. Cook Synthesis of Optically Active Subtype Selective BZR Ligands,”, Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, Sept. 10-14, 2006, MEDI-502.

Clayton, T., Prodrug Design and Synthesis, Graduate Seminar, Milwaukee, WI 2004.

Clayton, T., Stripping Potentiometry Studies of Inorganic Arsenic Oxyanions at Trace Levels, Awards Day Finalist, Milwaukee, WI, 2003.

Clayton, T., Chemistry and Art. National Chemistry Week. Discovery World, ACS - Milwaukee Section, Milwaukee, WI, 2001.