Ph.D., Brown University 2002
Key Areas of Interests:
Sleep and Brain Rhythms
Optogenetic Dissection of Neuronal Circuits
Teaching and Research Interests:
We are interested in how different regions in the brain coordinate to encode, store, and transfer information.
The brain generates an assortment of neuronal oscillations that vary depending on the behavior and state of the animal, from active exploration to resting and different stages of sleep. Accordingly, in our recordings of large populations of spiking neurons we observe state-dependent temporal relationships at multiple timescales. What role do these unique spike patterns play and what do they tell us about the function of each brain state? To answer these and related questions, we combine behavioral studies of learning and exploring rats, multi-channel recordings of the simultaneous electrical (spiking) activity from hundreds of neurons during behavior and sleep, and optogenetics (based on virus-mediated light-activated ion channels and pumps) to excite and silence specific neural populations in precise time windows during learning, consolidation and recall.
We are currently looking for students with an interest in neurophysiology. Quantitative skills (statistics and signal processing), programming skills and appreciation of electronics are helpful; a desire to learn is essential.
Psych 954: Seminar in Physiological Psychology: Reactivation, Recall, and Memory Consolidation
Psych 933: Seminar in Neuroscience
Psych 210: Psychological Statistics
Gilmartin MR, Miyawaki H, Helmstetter FJ, Diba K (2013) Prefrontal activity links nonoverlapping events in memory. J Neurosci 33: 10910-10914, PMID: 23804110.
Vizuete JA, Pillay S, Diba K, Ropella KM, Hudetz AG (2012) Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia. Front Integr Neurosci 6:90, PMID:23091451.
Grosmark AD, Mizuseki K, Pastalkova E, Diba K, Buzsaki G (2012) REM Sleep Reorganizes Hippocampal Excitability. Neuron 75:1001-1007, PMID:22998869.
Kempter R, Leibold C, Buzsaki G, Diba K, Schmidt R (2012) Quantifying circular-linear associations: hippocampal phase precession. J Neurosci Methods 207:113-124, PMID:22487609.
Vandecasteele M, M S, Royer S, Belluscio M, Berenyi A, Diba K, Fujisawa S, Grosmark A, Mao D, Mizuseki K, Patel J, Stark E, Sullivan D, Watson B, Buzsaki G (2012) Large-scale recording of neurons by movable silicon probes in behaving rodents. J Vis Exp:e3568, PMID:22415550.
Mizuseki K, Royer S, Diba K, Buzsaki G (2012) Activity dynamics and behavioral correlates of CA3 and CA1 hippocampal pyramidal neurons. Hippocampus 22:1659-80, PMID:22367959.
Mizuseki K, Diba K, Pastalkova E, Buzsaki G (2011) Hippocampal CA1 pyramidal cells form functionally distinct sublayers. Nat Neurosci 14:1174-1181, PMID:21822270.
Sullivan D, Csicsvari J, Mizuseki K, Montgomery S, Diba K, Buzsaki G (2011) Relationships between hippocampal sharp waves, ripples, and fast gamma oscillation: influence of dentate and entorhinal cortical activity. J Neurosci 31:8605-8616, PMID:21653864.
Buzsaki G, Diba K (2010) Oscillation-supported information processing and transfer in the hippocampus-entorhinal-neocortical interface. In: Dynamic Coordination in the Brain: From Neurons to Mind (von der Malsburg C, Phillips WA, Singer W, eds). Cambridge, MA: MIT Press.
Geisler C, Diba K, Pastalkova E, Mizuseki K, Royer S, Buzsaki G (2010) Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampus. Proc Natl Acad Sci U S A 107:7957-7962, PMID:20375279.
Schmidt R, Diba K, Leibold C, Schmitz D, Buzsaki G, Kempter R (2009) Single-trial phase precession in the hippocampus. J Neurosci 29:13232-13241, PMID:19846711. Diba K, Buzsaki G (2008) Hippocampal network dynamics constrain the time lag between pyramidal cells across modified environments. J Neurosci 28:13448-13456, PMID:19074018.
Diba K, Buzsaki G (2007) Forward and reverse hippocampal place-cell sequences during ripples. Nat Neurosci 10:1241-1242, PMID:17828259.