Office: Garland Hall 314
Phone: (414) 229-6665
Web Site: TBD
Ph.D., University of Lethbridge, Alberta, Canada, 2005
My research is focused on understanding brain changes as early predictors of cognitive deficits and dementia, and the role for hormones and genetic background as modulators of age-related cognitive decline. The function of the hippocampus and the nature of amnesia in aging and Alzheimer's disease are of particular interest. I employ a multi-level investigative approach that combines neurogenetics, neuroimaging and cognitive tasks that allow for cross-species comparisons.
Our lab is currently pursuing the following research objectives:
- Investigating the nature of genetic risk for age-related cognitive decline, the underlying neural circuitry and dynamics, and the role of hormone treatment as a modifier.
- Investigating factors that reduce the risk of cognitive decline and dementia. Understanding the factors that protect some individuals from impairment and contribute to the maintenance of cognitive health will continue to underlie future efforts.
- Understanding the function of the hippocampal formation and the anatomical and functional organization of learning and memory, in general, through development of tasks that allow for cross-species comparisons.
Driscoll I, Zhou Y, An Y, Sojkova J, Davatzikos C, Kraut MA, Ye W, Ferrucci L, Mathis CA, Klunk WE, Wong DF, Resnick SM (in press). 11C-PiB retention shows no association with longitudinal brain atrophy in nondemented elderly individuals. Neurobiology of Aging.
Driscoll I, Davatzikos C, An Y, Wu X, Shen D, Kraut M, Resnick SM (2009). Longitudinal pattern of regional brain volume change differentiates normal aging from MCI. Neurology 72(22):1906-1913.
O'Brien RJ, Resnick SM, Zonderman AB, Ferrucci L, Crain BJ, Pletnikova O, Rudow G, Iacono D, Riudavets MA, Driscoll I, Price DL, Martin LJ, Troncoso JC. Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA). J Alzheimer's Dis. 2009 Aug 3. [Epub ahead of print]
Monfils MH, Driscoll I, Vavrek R, Kolb B, Fouad K (2008). FGF-2-induced functional improvement from neonatal motor cortex injury via corticospinal projections. Exp Brain Res 185(3):453-60.
Driscoll I, Hong NS, Craig LA, Sutherland RJ, McDonald RJ (2008).Enhanced cell death and learning deficits after a mini-stroke in aged hippocampus. Neurobiol Aging 29(12);1847-1858.
Driscoll I, Resnick SM (2007). Testosterone and cognition in normal aging and Alzheimer’s disease: An update. Current Alzheimer Research 4 (1): 33-45. Review.
Resnick SM, Driscoll I, Lamar M. Vulnerability of the Orbitofrontal Cortex to Age-Associated Structural and Functional Brain Changes (2007). Ann N Y Acad Sci 1121:562-75. Review.
Driscoll I, Monfils MH, Flynn C, Teskey GC, Kolb B (2007). Neurophysiological properties of cells filling the neonatal medial prefrontal cortex lesion cavity. Brain Res 1178:38-43.
Driscoll I, Resnick SM, Troncoso JC, An Y, O’Brien R,Zonderman AB (2006). Impact of Alzheimer pathology on cognitive trajectories in non-demented elderly. Annals of Neurology 60 (6), 688-695.
Monfils MH, Driscoll I, Melvin NR, Kolb B (2006). Differential expression of basic fibroblast growth factor-2 in the developing rat brain. Neuroscience 141 (1), 213-221.
Driscoll I, Howard SR, JC Stone, Monfils MH, Tomanek B, Brooks WM, Sutherland RJ (2006). The aging hippocampus: A multilevel analysis in the rat. Neuroscience 139 (4), 1173-1185.
Monfils MH, Driscoll I, Kamitakahara H, Wilson B, Flynn C, Teskey GC, Kleim JA, Kolb B. (2006). FGF-2 induced cell proliferation stimulates anatomical, neurophysiological, and functional recovery from neonatal motor cortex injury. European Journal of Neuroscience 24, 739-749.
Driscoll I, Sutherland RJ (2005). The aging hippocampus: Navigating between rat and human findings. Reviews in the Neurosciences 16, 87-121. Review.
Monfils MH, Bray DF, Driscoll I, Kleim JA, Kolb B (2005). A quantitative comparison of synaptic density following perfusion vs. immersion fixation in the rat cerebral cortex. Microscopy Research and Technique 67 (6), 300-304.
Driscoll I, Howard SR, Prusky GT, Rudy JW, Sutherland RJ (2005).Seahorse wins all races: Hippocampus participates in both Linear and Non-Linear Visual Discrimination Learning. Behavioural Brain Research 164, 29-35.
Moses SN, Cole C, Driscoll I, Ryan J. (2005). Differential contributions of hippocampus, amygdala and perirhinal cortex to recognition of novel objects, contextual stimuli and stimulus relationships. Brain Research Bulletin 67, 62-76.
Monfils M-H, Driscoll I, Danka D, VandenBerg PM, Thomas N, Kleim JA, Kolb B (2005). BFGF stimulates functional recovery after neonatal lesions of motor cortex in rats. Neuroscience 134, 1-8.
Driscoll I, Hamilton DA, Yeo RA, Brooks WM, & Sutherland RJ (2005). Virtual navigation in humans: The impact of age and sex on place learning. Hormones and Behavior 47, 326-335.
Driscoll I, Guynn MJ, & McDaniel MA (2005). Apolipoprotein E and Prospective Memory in Normally Aging Humans. Neuropsychology 19, 28-34.