Krista M. Lisdahl
Formerly Krista Lisdahl Medina
Ph.D., University of Cincinnati, 2005
The Brain Imaging and Neuropsychology (BraIN) Laboratory at UW-Milwaukee. The primary focus of the BraIN Lab is on the neurocognitive consequences of chronic drug use during adolescence and young adulthood. More specifically, using magnetic resonance imaging (structural MRI, functional MRI and diffusion tensor imaging) and neuropsychological assessment, we examine the effects of marijuana, alcohol, nicotine and ecstasy on brain structure and function. We also attempt to explain individual differences by examining whether gender, genetics (e.g., 5-HTTLPR, BDNF, COMT, NRG1, FAAH, KIBRA), or lifestyle factors (body mass index, cardiorespiratory health, activity markers) moderate these effects. We are also interested in studying these issues in healthy developing teens and young adults. Currently, we are running a NIH/NIDA funded study (R01 DA030354) examining whether physical activity levels or cardiorespiratory fitness moderate the effects of chronic marijuana use on frontolimbic connectivity in teens and emerging adults.
2012: Received a Presidential Early Career Award for Scientists and Engineers (PECASE) from President Obama and the National Institute of Health (NIH).
2011: Received the NIDA Division of Clinical Neuroscience and Behavioral Research, Behavioral and Brain Development 2011 Outstanding Early Career Investigator Award.
Clinical neuropsychology, assessment, psychopharmacology, effects of drugs on behavior.
Medina, K.L., Shear, P.K., & Corcoran, K. (2005). Ecstasy (MDMA) exposure and neuropsychological functioning: A polydrug perspective. Journal of the International Neuropsychological Society, 11(6), 1-13.
Pagulayan, K.F., Busch, R., Medina, K.L., & Krikorian, R. (2006). Developmental normative data for the Corsi Block-Tapping Test. Journal of Clinical and Experimental Neuropsychology, 28 (6), 1043-1052.
Medina, K.L., Shear, P.K., & Schafer, J. (2006). Memory functioning in polysubstance dependent women. Drug and Alcohol Dependence, 84(3), 248-55.
Nagel, B.J., Medina, K.L., Yoshii, J., Schweinsburg, A.D., Moadab, I., & Tapert, S.F. (2006). Age related changes in prefrontal white matter volume across adolescence. NeuroReport, 17(13), 1427-31.
Medina, K.L. & Shear, P.K. (2007). Anxiety, depression & behavioral symptoms of executive dysfunction in ecstasy users: Contributions of polydrug use. Drug and Alcohol Dependence, 87, 303-311.
Medina, K.L., Schweinsburg, A.D., Cohen-Zion, M., Nagel, B.J., & Tapert, S.F. (2007). Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal asymmetry. Exposures During Adolescent Development: Are Neurotoxic Risks Increased? Neurotox and Teratology, 29, 141-152.
Medina, K.L., Nagel, B.J., McQueeny, T., Park, A., & Tapert, S.F. (2007). Depressive symptoms in adolescents: Associations with white matter volume and marijuana use. Journal of Child Psychology and Psychiatry, 48(6), 592-600.
Medina, K.L., Hanson, K., Schweinsburg, A.D., Cohen-Zion, M., Nagel, B.J., & Tapert, S.F. (2007). Neuropsychological functioning in adolescent marijuana users: Subtle deficits detectable after 30 days of abstinence. Journal of the International Neuropsychological Society, 13(5), 807-820.
Medina, K.L., McQueeny, T., Nagel, B.J., Hanson, K., Schweinsburg, A.D., & Tapert, S.F. (2008). Prefrontal cortex volumes in adolescents with alcohol use disorders: Unique gender effects. Alcohol Clinical and Experimental Research, 32, 386-94.
Medina, K.L., McQueeny, T., Nagel, B.J., Hanson, K.L., Yang, T., & Tapert, S.F. (2009). Prefrontal morphometry in abstinent adolescent marijuana users: Subtle gender effects. Addiction Biology, 14(4), 457-68.
Cohen-Zion, M., Drummong, S.P.A., Padula, C.B., Winward, J., Kanady, J., Medina, K.L., & Tapert, S.F. (2009). Sleep Architecture in Adolescent Marijuana and Alcohol Users during Acute and Extended Abstinence. Addictive Behaviors, 34(11), 967-9.
Medina, K.L., Nagel, B.J., & Tapert, S.F. (2010). Cerebellar vermis abnormality in adolescent marijuana users. Psychiatry Research: Neuroimaging, 182(2), 152-159.
Hanson, K. L., Medina, K. L., Nagel, B. J., Spadoni, A. D., Gorlick, A., & Tapert, S. F. (2010). Hippocampal volumes in adolescents with and without a family history of alcoholism. The American Journal of Drug and Alcohol Abuse, 36, 161-167.
Schweinsburg, A.D., Schweinsburg, B.C., Medina, K.L., McQueeny, T., Brown, S.A., & Tapert, S.F. (2010). The influence of recency of use on fMRI response during spatial working memory in adolescent marijuana users. Journal of Psychoactive Drugs, 42(3), 401-12.
Hanson, K. L., Winward, J. L., Schweinsburg, A. D., Medina, K. L., Brown, S. A., & Tapert, S. F. (2010). Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence. Addictive Behaviors, 35(11):970-6.
Hanson, K.L., Medina, K.L., Padula, C.B., Tapert, S.F., & Brown, S.A. (2011). How does adolescent alcohol and drug use affect neuropsychological functioning in young adulthood?: 10-year outcomes. Journal of Child & Adolescent Substance Abuse, 20, 135-154.
McQueeny, T.M., Padula, C., Price, J., Lisdahl, K.M., Logan, P., & Tapert, S.F. (in press). Gender effects on amygdala morphometry in adolescent marijuana users. Behavioural Brain Research.
Lisdahl, K.M. & Price, J.S. (in press). Increased marijuana use and gender predict poorer cognitive functioning in healthy emerging adults. Journal of the International Neuropsychological Society.