Office: Garland Hall 238E
Phone: (414) 229-6113
Ph.D., Concordia University (Montreal, Canada), 2005
Our lab researches the neural mechanisms of learning and memory as they pertain to drug use and emotional regulation, with emphasis on neurophysiology.Compulsive drug seeking and drug taking are the hallmarks of addiction, and overcoming these behaviors has proven difficult.Regulating these behaviors can be achieved by enhancing extinction learning and inhibiting retrieval of drug-associated memories.Recent work in the lab has shown that drug seeking can be reduced or eliminated using a variety of pharmacological manipulations, and the neural mechanisms are currently under study.We use animal models of drug administration combined with electrophysiological (in vivo and in vitro), pharmacological, and molecular techniques.Understanding the neural bases of extinction and drug-associated memory retrieval could lead to the development of pharmacotherapies that improve therapeutic outcome of rehabilitation programs.
Research assistant positions are available to qualified students. Please feel free to contact me for further details.
Behavioral Neuroscience; Neurobiology of Learning and Memory; Neurobiology of Addiction; Psychopharmacology
Psych 454: Psychopharmacology & Addiction
Psych 611: Neurobiology of Drug Addiction
Psych 611/711: Cellular and Molecular Neuroscience
Psych 654: Advanced Physiological Psychology
Psych 854: Behavioral Neuroscience
Hafenbreidel, M., Rafa Todd, C., Twining, R.C., Tuscher, J.J., and Mueller, D. (2014). Bidirectional effects of inhibiting or potentiating NMDA receptors on extinction after cocaine self-administration in rats.Psychopharmacology, Epub ahead of print (May 22).
Otis, J.M., Fitzgerald, M.K., and Mueller, D. (2014).Infralimbic BDNF/TrkB enhancement of GluN2B currents facilitates extinction of a cocaine-conditioned place preference.The Journal of Neuroscience, 34, 6057-6064.
Otis, J.M., Fitzgerald, M.K., and Mueller, D. (2014).Inhibition of hippocampal β-adrenergic receptors impairs retrieval but not reconsolidation of cocaine-associated memory and prevents subsequent reinstatement. Neuropsychopharmacology, 39, 303-310.
Twining, R.C., Tuscher, J.J., Doncheck, E.M., Frick, K.M. and Mueller, D. (2013).17β-Estradiol is necessary for extinction of cocaine seeking in female rats.Learning & Memory, 20, 300-306.
Otis, J.M., Dashew, K.D., and Mueller, D. (2013).Neurobiological dissociation of retrieval and reconsolidation of cocaine-associated memory. The Journal of Neuroscience, 33, 1271-1281.
Otis, J.M., and Mueller, D. (2011).Inhibition of β-adrenergic receptors induces a persistent deficit in retrieval of a cocaine-associated memory providing protection against reinstatement.Neuropsychopharmacology , 36, 1912-1920.
Mueller, D. and Cahill, S.P. (2010). Noradrenergic modulation of extinction learning and exposure therapy. Behavioural Brain Research, 208, 1-11.