Office: Garland Hall 238E
Phone: (414) 229-6113
Ph.D., Concordia University (Montreal, Canada), 2005
Our lab researches the neural mechanisms of learning and memory as they pertain to drug use and emotional regulation, with emphasis on neurophysiology.Compulsive drug seeking and drug taking are the hallmarks of addiction, and overcoming these behaviors has proven difficult.Regulating these behaviors can be achieved by enhancing extinction learning and inhibiting retrieval of drug-associated memories.Recent work in the lab has shown that drug seeking can be reduced or eliminated using a variety of pharmacological manipulations, and the neural mechanisms are currently under study.We use animal models of drug administration combined with electrophysiological (in vivo and in vitro), pharmacological, and molecular techniques.Understanding the neural bases of extinction and drug-associated memory retrieval could lead to the development of pharmacotherapies that improve therapeutic outcome of rehabilitation programs.
Research assistant positions are available to qualified students. Please feel free to contact me for further details.
Behavioral Neuroscience; Neurobiology of Learning and Memory; Neurobiology of Addiction; Psychopharmacology
Psych 454: Psychopharmacology & Addiction
Psych 611: Neurobiology of Drug Addiction
Psych 654: Advanced Physiological Psychology
Psych 854: Behavioral Neuroscience
Otis, J.M., and Mueller, D. (2011).Inhibition of β-adrenergic receptors induces a persistent deficit in retrieval of a cocaine-associated memory providing protection against reinstatement. Neuropsychopharmacology, 36, 1912-1920.
Mueller, D., and De Wit, H. (2011).Conditioned place preference in rodents and humans.In J. Raber (Ed.), Animal Models of Behavioral Analysis (pp. 133-152).New York: Humana Press.
Mueller, D., Bravo-Rivera, C., and Quirk, G.J. (2010).Infralimbic D2 receptors are necessary for fear extinction and neuronal tone responses. Biological Psychiatry, 68, 1055-60.
Mueller, D., and Cahill, S.P. (2010).Noradrenergic modulation of extinction learning and exposure therapy.Behavioural Brain Research, 208, 1-11.
Afonso, V.M., Mueller, D., Stewart, J., and Pfaus, J.G. (2009).Amphetamine pretreatment facilitates appetitive sexual behaviors in the female rat.Psychopharmacology, 205,35-43.
Mueller, D., Olivera-Figueroa, L.A., Pine, D.S., and Quirk, G.J. (2009).The effects of yohimbine and amphetamine on fear extinction. Psychopharmacology, 204, 599-606.
Rodriguez-Romaguera, J., Sotres-Bayon, F., Mueller, D., and Quirk, G.J. (2009).Systemic propranolol acts centrally to reduce expression of cued fear in rats without impairing extinction learning. Biological Psychiatry, 65, 887-892.
Mueller, D., Porter, J.T., and Quirk, G.J. (2008). Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction. Journal of Neuroscience, 28, 369-375.
Quirk, G.J., and Mueller, D. (2008).Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology, 33, 56-72.
Mueller, D., Chapman, C.A., and Stewart, J. (2006).Amphetamine induces dendritic growth in ventral tegmental area dopaminergic neurons in vivo via basic fibroblast growth factor. Neuroscience, 137, 727-735.
Mueller, D., Perdikaris, D., and Stewart, J. (2002).Persistence and drug-induced reinstatement of a morphine-induced conditioned place preference. Behavioural Brain Research, 136, 389-397.
Mueller, D., and Stewart, J. (2000).Cocaine-induced conditioned place preference:Reinstatement by priming injections of cocaine after extinction. Behavioural Brain Research, 115, 39-47.