Office of Undergraduate Research

Zebrafish as a Model for Studying Neurodegeneration and Dementias in Humans

We use zebrafish as a model system for looking at how genes and environment interact to cause defects in the nervous system. We are particularly interested in how exposure of embryos to common environmental contaminants (e.g. mercury, lead etc.) at levels that cause no observable affect can cause a break down in the nervous system of adult animals. Similarly, we also look at the effects of introducing human genes implicated in Alzheimer's disease on the fish nervous system.

This project is located at the School of Freshwater Science: 600 E. Greenfield Ave. Milwaukee, WI 53204

***Campus Shuttle Service to The School of Freshwater Science is now available!*** https://www4.uwm.edu/freshwater/

Tasks and responsibilities:

Zebrafish husbandry: Including feeding, spawning, collecting and observing embryos and larval fish. Microscopy: Using stereomicroscopes, inverted and upright microscopes and recording observations using high end CCD cameras. Molecular Biology: RNA/DNA isolation, polymerase chain reaction Bioinformatics.