Office of Undergraduate Research

Intrauterine and perinatal Bisphenol A exposure and neonatal body composition

Our overall hypothesis is that early life human exposure to a specific environmental obesogen bisphenol A (BPA), increases body fat and the risk of obesity. Funding success will necessitate preliminary data demonstrating feasibility, methods validity and effect size information for optimal study design for later proposals. Human BPA exposure is widespread, yet human studies of BPAs impact on body fat have not been conducted. Objective. 1 is to test recruitment feasibility of measuring neonatal body composition by ADP and DXA methods within first 48 hours after birth. Objective 2 is to evaluate the concordance between body fat values determined by ADP and DXA in a neonatal population. Objective 3 is to estimate the mean and sampling distribution for each of the measures of neonatal body composition overall and by intrauterine and perinatal BPA exposure (measured in maternal and infant urine, and meconium). Objective 4 is to develop and validate a method to measure BPA in infant meconium

Tasks and responsibilities:

Assist with data collection, data checking, and summarization and presentation of findings. The student will work on and refine evidence tables that will go in each at least two of the manuscripts from this study.