Mechanism by which apoaequorin protects neurons from an ischemic stroke
Ischemia (stroke) causes excess calcium levels, which kills neurons. We demonstrated that the calcium binding protein apoaequorin (AQ) protects neurons from ischemic cell death. Furthermore, we also recently demonstrated that AQ upregulates the anti-inflammatory cytokine interleukin-10 (IL-10). Thus, our recent data suggest that in addition to buffering intracellular calcium, AQ may also protect neurons by altering cytokine expression.