University Safety and Assurances

Chapter 7 - Additional Laboratory Personnel Protection for Work with Particularly Hazardous Substances

Chapter 7pdf version, Adobe Acrobat Required (for printing)


Additional laboratory personnel protection will be considered for work with particularly hazardous substances. These include “select carcinogens,” reproductive toxins, and substances that have a high degree of acute toxicity (see Appendix B). Pp. 90-93 of Prudent Practices provides detailed recommendations for work with particularly hazardous substances. Laboratory supervisors and Principal Investigators are responsible for assuring that laboratory procedures involving particularly hazardous chemicals have been evaluated for the level of laboratory personnel protection required. Specific consideration will be given to the need for inclusion of the following provisions:

  1. Planning;
  2. Establishment of a designated area- can indicate areas on Laboratory Signage Program or post sign warning of use in specified area; 
  3. Access control;
  4. Special precautions such as:
    • use of containment devices such as fume hoods or glove boxes;
    • use of personal protective equipment;
    • isolation of contaminated equipment;
    • practicing good laboratory hygiene; and
    • prudent transportation of very toxic chemicals.
  5. Planning for accidents and spills; and
  6. Special storage and waste disposal practices.